ACSM1

Across TCGA patient cohorts, ACSM1 mutation is significantly associated with the total protein of many other genes, with 58 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACSM1-associated genes across cancer lineages are Src_pY416, ATM, and GAPDH. Each is linked with ACSM1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ACSM1-to-partner and partner-to-ACSM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src_pY416 grouped by ACSM1-low versus ACSM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACSM1→partner) and Y-score (partner→ACSM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Src_pY416 →	-0.162	-1.501	.048	.015	3	3
UCEC	ATM →	-0.452	-1.794	.003	.024	3	3
SKCM	GAPDH →	+0.353	+1.058	.041	.035	3	2
SKCM	GSK3-a-b →	+0.119	+1.584	.009	.007	3	2
SKCM	HSP70 →	-0.466	-3.169	.002	<.001	3	2
SKCM	Paxillin →	+0.247	+1.765	.041	.012	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 58 associations by consensus.

Src_pY416 by ACSM1 expression — UCEC

Explore this box plot interactively →