ACSL6

Across TCGA patient cohorts, ACSL6 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACSL6-associated genes across cancer lineages are STAT3_pY705, TFRC, and 4E-BP1. Each is linked with ACSL6 in more than 2 cancer types. Because this analysis shows association rather than direction, both ACSL6-to-partner and partner-to-ACSL6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by ACSL6-low versus ACSL6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACSL6→partner) and Y-score (partner→ACSL6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.285	-1.280	<.001	.049	3	3
SKCM	TFRC →	+0.623	+2.321	.006	.032	3	3
UCEC	4E-BP1 →	+0.225	+2.807	.008	.002	3	3
LUSC	NF2 →	+0.235	+2.816	.049	.036	3	2
COAD	ATM →	-0.708	-2.991	<.001	.036	2	3
UCEC	p27_pT198 →	+0.086	+1.353	.011	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

STAT3_pY705 by ACSL6 expression — UCEC

Explore this box plot interactively →