ACSL3-AS1

Across TCGA pan-cancer cohorts, ACSL3-AS1 RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated ACSL3-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher ACSL3-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ACSL3-AS1 expression acts as an unfavorable survival marker, although some lineages such as PAAD and PRAD show a favorable association.

UVM, KICH, and ACC are the cancer types where ACSL3-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.528	0.957	<.001	129	view →
KICH	DFS	Tertile	All	0.607	1.000	<.001	102	view →
ACC	OS	Median	All	0.448	0.780	<.001	95	view →
READ	DFS	Median	II,III,IV	0.675	0.937	.004	54	view →
THCA	OS	Median	All	0.983	0.997	.007	45	view →
UCEC	DFS	Median	All	0.867	0.926	.001	26	view →
MESO	OS	Quartile	IV	0.277	0.794	.020	21	view →
SKCM	DFS	Tertile	IV	0.073	0.580	.001	18	view →
LGG	OS	Median	All	0.850	0.932	<.001	16	view →
PAAD	OS	Quartile	All	0.761	0.500	.020	14	view →
SARC	DFS	Quartile	All	0.258	0.447	.008	13	view →
PRAD	DFS	Tertile	All	0.932	0.825	.002	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

ACSL3-AS1–UVM (DFS)

Open the UVM breakdown →