ACSL1

Across TCGA patient cohorts, ACSL1 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACSL1-associated genes across cancer lineages are ATM, p38-MAPK_pT180_Y182, and PDCD4. Each is linked with ACSL1 in more than 2 cancer types. Because this analysis shows association rather than direction, both ACSL1-to-partner and partner-to-ACSL1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ACSL1-low versus ACSL1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACSL1→partner) and Y-score (partner→ACSL1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.486	-1.514	.001	.015	3	3
UCEC	p38-MAPK_pT180_Y182 →	-0.377	-1.501	.013	.015	3	2
UCEC	PDCD4 →	-0.457	-1.514	.004	.015	3	2
UCEC	TIGAR →	+0.106	+1.274	.042	.028	3	2
UCEC	Caspase-7-cleavedD198 →	+0.599	+2.107	.002	.002	3	2
UCEC	4E-BP1 →	+0.435	+2.137	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

ATM by ACSL1 expression — UCEC

Explore this box plot interactively →