ACR

Across TCGA patient cohorts, ACR RNA expression is significantly associated with the go_rna of many other GO terms, with 7,140 significant associations in total. KIRC shows the largest number of these associations.

The most reproducible ACR-associated GO terms across cancer lineages are Actin filament bundle organization, Notch signaling pathway, and Protein stabilization. Each is linked with ACR in more than 23 cancer types. Because this analysis shows association rather than direction, both ACR-to-partner and partner-to-ACR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Actin filament bundle organization grouped by ACR-low versus ACR-high in ESCA.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ACR→partner) and Y-score (partner→ACR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
ESCA	Actin filament bundle organization →	+0.066	+0.253	<.001	<.001	3	24
ESCA	Notch signaling pathway →	+0.055	+0.226	<.001	<.001	3	24
STAD	Protein stabilization →	+0.051	+0.197	<.001	<.001	3	24
STAD	Focal adhesion assembly →	+0.068	+0.150	<.001	<.001	3	24
STAD	Regulation of actin filament bundle assembly →	+0.062	+0.191	<.001	<.001	3	24
ESCA	Hematopoietic stem cell homeostasis →	+0.065	+0.290	<.001	<.001	3	23

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,140 associations by consensus.

Actin filament bundle organization by ACR expression — ESCA

Explore this box plot interactively →