ACR

Across TCGA patient cohorts, ACR protein abundance is significantly associated with the RNA expression of many other genes, with 182 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ACR-associated genes across cancer lineages are FBXO7, ZNRF4, and NR4A3. Each is linked with ACR in more than 1 cancer types. Because this analysis shows association rather than direction, both ACR-to-partner and partner-to-ACR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ACR versus FBXO7 in GBM, with a Pearson correlation of 0.92.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACR→partner) and Y-score (partner→ACR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FBXO7 →	+0.688	+0.937	.006	.002	3	1
GBM	ZNRF4 →	+0.086	+0.750	.001	.004	3	1
GBM	NR4A3 →	+2.723	+0.993	.004	.004	3	1
GBM	TSHB →	+0.310	+0.995	.001	.001	3	1
GBM	CMPK2 →	+1.496	+1.080	.004	.006	3	1
GBM	IL24 →	+0.163	+0.688	.003	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 182 associations by consensus.

ACR vs FBXO7 — GBM

Explore this scatter interactively →