ACR

Across TCGA patient cohorts, ACR mutation is significantly associated with the total protein of many other genes, with 7 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACR-associated genes across cancer lineages are JNK2, p62 Lck ligand, and PCNA. Each is linked with ACR in more than 1 cancer types. Because this analysis shows association rather than direction, both ACR-to-partner and partner-to-ACR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK2 grouped by ACR-low versus ACR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACR→partner) and Y-score (partner→ACR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.259	+3.009	.012	.019	3	1
UCEC	p62 Lck ligand →	+0.425	+3.321	.012	.010	3	1
UCEC	PCNA →	+0.248	+3.000	.028	.036	3	1
UCEC	Shc_pY317 →	-0.218	-3.000	.006	.036	3	1
UCEC	Caspase-8 →	-0.328	-2.973	.012	.035	3	1
UCEC	Chk2_pT68 →	-0.202	-2.990	.038	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 7 associations by consensus.

JNK2 by ACR expression — UCEC

Explore this box plot interactively →