Across TCGA patient cohorts, ACP7 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACP7-associated genes across cancer lineages are MSH2, MSH6, and Caspase-7-cleavedD198. Each is linked with ACP7 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACP7-to-partner and partner-to-ACP7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACP7→partner) and Y-score (partner→ACP7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MSH2 →	-0.305	-2.974	.008	.035	3	2
UCEC	MSH6 →	-0.339	-3.169	.012	.018	3	2
UCEC	Caspase-7-cleavedD198 →	+0.801	+2.019	.001	.017	3	2
UCEC	eEF2 →	+0.475	+2.321	.001	.006	3	1
UCEC	EGFR_pY1068 →	-0.291	-1.807	.004	.027	3	1
UCEC	A-Raf_pS299 →	-0.137	-3.459	.005	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Exploration

ACP7 survival (RNA) · tumor vs normal (RNA) · all ACP7 data types