ACP6

Across TCGA patient cohorts, ACP6 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACP6-associated genes across cancer lineages are ERK2, Lck, and MSH2. Each is linked with ACP6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACP6-to-partner and partner-to-ACP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by ACP6-low versus ACP6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACP6→partner) and Y-score (partner→ACP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.219	+1.906	.004	.016	3	1
UCEC	Lck →	+0.192	+2.321	.017	.034	3	1
UCEC	MSH2 →	-0.354	-2.415	<.001	.003	3	1
UCEC	Annexin-1 →	+0.819	+3.604	<.001	.001	3	1
UCEC	ATM →	-0.612	-2.700	<.001	.006	3	1
UCEC	Caspase-7-cleavedD198 →	+0.731	+2.415	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

ERK2 by ACP6 expression — UCEC

Explore this box plot interactively →