ACP5

Across TCGA patient cohorts, ACP5 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACP5-associated genes across cancer lineages are MSH6, Akt, and PKC-delta_pS664. Each is linked with ACP5 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACP5-to-partner and partner-to-ACP5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by ACP5-low versus ACP5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACP5→partner) and Y-score (partner→ACP5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH6 →	-0.414	-2.311	.004	.034	3	2
UCEC	Akt →	-0.243	-2.115	.015	.019	3	2
UCEC	PKC-delta_pS664 →	-0.111	-3.169	.034	.018	3	2
UCEC	VHL →	-0.891	-3.169	.002	.018	3	2
UCEC	Bax →	+0.216	+2.807	.039	.003	3	2
UCEC	Caspase-7-cleavedD198 →	+0.880	+1.894	<.001	.030	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

MSH6 by ACP5 expression — UCEC

Explore this box plot interactively →