ACP2

Across TCGA patient cohorts, ACP2 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACP2-associated genes across cancer lineages are MAPK_pT202_Y204, Notch1, and Rictor_pT1135. Each is linked with ACP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACP2-to-partner and partner-to-ACP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAPK_pT202_Y204 grouped by ACP2-low versus ACP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACP2→partner) and Y-score (partner→ACP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAPK_pT202_Y204 →	-0.466	-3.000	.033	.036	3	1
UCEC	Notch1 →	+0.235	+3.335	<.001	.005	3	1
UCEC	Rictor_pT1135 →	-0.100	-2.584	.036	.011	3	1
UCEC	TIGAR →	+0.196	+1.901	.005	.031	3	1
UCEC	Caspase-7-cleavedD198 →	+1.225	+3.479	<.001	.002	3	1
UCEC	4E-BP1 →	+0.280	+2.837	.026	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

MAPK_pT202_Y204 by ACP2 expression — UCEC

Explore this box plot interactively →