ACOX3

Across TCGA patient cohorts, ACOX3 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACOX3-associated genes across cancer lineages are mTOR_pS2448, Caspase-7-cleavedD198, and eIF4E. Each is linked with ACOX3 in more than 2 cancer types. Because this analysis shows association rather than direction, both ACOX3-to-partner and partner-to-ACOX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by ACOX3-low versus ACOX3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACOX3→partner) and Y-score (partner→ACOX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.125	-1.906	.008	.004	3	3
UCEC	Caspase-7-cleavedD198 →	+0.733	+1.604	<.001	.010	3	3
UCEC	eIF4E →	+0.180	+2.502	.007	.001	3	2
UCEC	MSH6 →	-0.295	-1.700	.005	.040	3	2
UCEC	PCNA →	+0.223	+1.807	.001	.003	3	2
UCEC	PDK1_pS241 →	+0.121	+2.000	.027	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

mTOR_pS2448 by ACOX3 expression — UCEC

Explore this box plot interactively →