ACOX3

Across TCGA cell cohorts, ACOX3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,742 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible ACOX3-associated GO terms across cancer lineages are Fatty acid beta-oxidation using acyl-CoA oxidase, Regulation of aggrephagy, and Positive regulation of aggrephagy. Each is linked with ACOX3 in more than 11 cancer types. Because this analysis shows association rather than direction, both ACOX3-to-partner and partner-to-ACOX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fatty acid beta-oxidation using acyl-CoA oxidase grouped by ACOX3-low versus ACOX3-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ACOX3→partner) and Y-score (partner→ACOX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Fatty acid beta-oxidation using acyl-CoA oxidase →	+0.115	+1.086	.002	.002	3	12
LUNG_SCLC	Regulation of aggrephagy →	+0.144	+0.858	<.001	<.001	3	12
CNS	Positive regulation of aggrephagy →	+0.167	+0.767	<.001	<.001	3	12
CNS	Positive regulation of CAMKK-AMPK signaling cascade →	+0.320	+0.696	.003	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Endosomal transport →	+0.060	+0.862	<.001	<.001	3	10
LARGE_INTESTINE	Positive regulation of mitophagy →	+0.084	+0.680	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,742 associations by consensus.

Fatty acid beta-oxidation using acyl-CoA oxidase by ACOX3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →