ACOX2

Across TCGA patient cohorts, ACOX2 mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACOX2-associated genes across cancer lineages are ATM, Bak, and EGFR_pY1068. Each is linked with ACOX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACOX2-to-partner and partner-to-ACOX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ACOX2-low versus ACOX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACOX2→partner) and Y-score (partner→ACOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.579	-2.459	<.001	<.001	3	2
UCEC	Bak →	+0.185	+3.169	.033	.018	3	2
UCEC	EGFR_pY1068 →	-0.244	-2.070	.005	.001	3	1
UCEC	eIF4G →	+0.267	+2.807	.013	.003	3	1
UCEC	A-Raf_pS299 →	-0.133	-2.115	.001	.017	3	1
UCEC	ERK2 →	+0.181	+1.678	.006	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

ATM by ACOX2 expression — UCEC

Explore this box plot interactively →