ACOX2

Across TCGA cell cohorts, ACOX2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,529 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ACOX2-associated GO terms across cancer lineages are Transposable element silencing by piRNA-mediated heterochromatin formation, Positive regulation of synapse structural plasticity, and Venous blood vessel morphogenesis. Each is linked with ACOX2 in more than 6 cancer types. Because this analysis shows association rather than direction, both ACOX2-to-partner and partner-to-ACOX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Transposable element silencing by piRNA-mediated heterochromatin formation grouped by ACOX2-low versus ACOX2-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ACOX2→partner) and Y-score (partner→ACOX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Transposable element silencing by piRNA-mediated heterochromatin formation →	+1.503	+1.420	<.001	.004	3	7
BLOOD_Leukemia	Positive regulation of synapse structural plasticity →	+1.052	+0.721	<.001	<.001	3	7
SOFT_TISSUE	Venous blood vessel morphogenesis →	+0.264	+1.026	.008	.001	3	6
LUNG_NSCLC_LUAD	Negative regulation of cardiac muscle hypertrophy →	+0.075	+1.241	.003	.005	3	6
BONE	Regulation of BMP signaling pathway →	+0.102	+1.363	<.001	.003	3	6
BLOOD_Leukemia	Peptidyl-tyrosine dephosphorylation →	+0.059	+0.585	.001	.009	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,529 associations by consensus.

Transposable element silencing by piRNA-mediated heterochromatin formation by ACOX2 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →