ACOX1

Across TCGA patient cohorts, ACOX1 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACOX1-associated genes across cancer lineages are Lck, Caspase-7-cleavedD198, and Caspase-8. Each is linked with ACOX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACOX1-to-partner and partner-to-ACOX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Lck grouped by ACOX1-low versus ACOX1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACOX1→partner) and Y-score (partner→ACOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Lck →	+0.176	+2.000	.025	.010	3	2
UCEC	Caspase-7-cleavedD198 →	+0.767	+2.827	<.001	.001	3	2
UCEC	Caspase-8 →	-0.223	-3.558	.024	.002	3	2
UCEC	eEF2 →	+0.307	+1.584	.029	.036	3	1
UCEC	ERK2 →	+0.231	+2.502	.002	.002	3	1
UCEC	FOXO3a_pS318_S321 →	-0.098	-1.797	.044	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Lck by ACOX1 expression — UCEC

Explore this box plot interactively →