Across TCGA patient cohorts, ACOT6 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACOT6-associated genes across cancer lineages are Rab25, BRD4, and Caspase-7-cleavedD198. Each is linked with ACOT6 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACOT6-to-partner and partner-to-ACOT6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACOT6→partner) and Y-score (partner→ACOT6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rab25 →	-0.422	-3.000	.015	.036	3	1
UCEC	BRD4 →	+0.301	+2.177	.032	.035	3	1
UCEC	Caspase-7-cleavedD198 →	+0.862	+3.019	.005	.019	3	1
UCEC	4E-BP1 →	+0.530	+3.199	<.001	.009	3	1
UCEC	Shc_pY317 →	-0.297	-3.321	<.001	.010	2	1
UCEC	VEGFR2 →	+0.318	+2.183	.041	.035	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Exploration

ACOT6 survival (RNA) · tumor vs normal (RNA) · all ACOT6 data types