ACOT4

Across TCGA patient cohorts, ACOT4 protein abundance is significantly associated with the RNA expression of many other genes, with 2,071 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible ACOT4-associated genes across cancer lineages are ACOT1, ADCK1, and ACOT2. Each is linked with ACOT4 in more than 3 cancer types. Because this analysis shows association rather than direction, both ACOT4-to-partner and partner-to-ACOT4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ACOT4 versus ACOT1 in BRCA, with a Pearson correlation of 0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACOT4→partner) and Y-score (partner→ACOT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	ACOT1 →	+0.757	+0.425	<.001	<.001	3	4
BRCA	ADCK1 →	+0.427	+0.432	.001	<.001	3	3
CCRCC	ACOT2 →	+0.539	+0.471	.001	<.001	3	3
CCRCC	ERG28 →	+0.368	+0.527	<.001	<.001	3	3
LUAD	ISCA2 →	+0.456	+0.369	<.001	<.001	3	3
BRCA	CCDC34 →	-0.756	-0.534	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,071 associations by consensus.

ACOT4 vs ACOT1 — BRCA

Explore this scatter interactively →