ACOT4

Across TCGA patient cohorts, ACOT4 mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACOT4-associated genes across cancer lineages are Erythrocytes, Neutrophils, and pDC. Each is linked with ACOT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACOT4-to-partner and partner-to-ACOT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Erythrocytes grouped by ACOT4-low versus ACOT4-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACOT4→partner) and Y-score (partner→ACOT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	Erythrocytes →	+0.019	+3.513	.024	.011	3	1
UCEC	Neutrophils →	+0.022	+1.581	<.001	.038	3	1
UCEC	pDC →	+0.045	+2.202	.038	.033	3	1
UCEC	Endothelial cells →	-0.037	-1.957	.030	.032	2	1
UCEC	Basophils →	+0.180	+2.000	.018	.032	2	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Erythrocytes by ACOT4 expression — LUAD

Explore this box plot interactively →