ACOT4

Across TCGA cell cohorts, ACOT4 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. OVARY shows the largest number of these associations.

The most reproducible ACOT4-associated genes across cancer lineages are SIGLEC7, CSHL1, and RBMY1J. Each is linked with ACOT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACOT4-to-partner and partner-to-ACOT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SIGLEC7 grouped by ACOT4-low versus ACOT4-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACOT4→partner) and Y-score (partner→ACOT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	SIGLEC7 →	+0.099	+4.209	<.001	.006	3	1
OVARY	CSHL1 →	+0.051	+4.450	.008	.004	3	1
OVARY	RBMY1J →	+0.017	+4.807	<.001	.003	3	1
CNS	HES3 →	+0.044	+5.321	<.001	.005	3	1
CNS	MTRNR2L6 →	+0.020	+6.357	<.001	<.001	3	1
BLOOD_Leukemia	MAGEB18 →	+0.098	+4.152	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

SIGLEC7 by ACOT4 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →