ACOT2

Across TCGA patient cohorts, ACOT2 protein abundance is significantly associated with the RNA expression of many other genes, with 2,431 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible ACOT2-associated genes across cancer lineages are NOP56, ALDH6A1, and ACOT1. Each is linked with ACOT2 in more than 2 cancer types. Because this analysis shows association rather than direction, both ACOT2-to-partner and partner-to-ACOT2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ACOT2 versus NOP56 in LSCC, with a Pearson correlation of -0.33.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACOT2→partner) and Y-score (partner→ACOT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	NOP56 →	-0.446	-0.386	.007	.005	3	3
CCRCC	ALDH6A1 →	+1.063	+0.319	<.001	.002	3	3
LSCC	ACOT1 →	+0.657	+0.513	<.001	.002	3	3
BRCA	NUDT1 →	-0.982	-1.045	<.001	.001	3	2
BRCA	PTPRB →	+0.802	+0.733	.001	.001	3	2
BRCA	NDFIP1 →	+0.533	+0.696	.008	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,431 associations by consensus.

ACOT2 vs NOP56 — LSCC

Explore this scatter interactively →