ACOT2

Across TCGA patient cohorts, ACOT2 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACOT2-associated genes across cancer lineages are GAPDH, Ku80, and MEK1. Each is linked with ACOT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACOT2-to-partner and partner-to-ACOT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by ACOT2-low versus ACOT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACOT2→partner) and Y-score (partner→ACOT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.584	+2.321	.030	.035	2	2
UCEC	Ku80 →	+0.309	+3.179	.009	.010	3	1
UCEC	MEK1 →	+0.472	+3.459	.010	.005	3	1
UCEC	Notch1 →	+0.215	+2.321	.002	.035	3	1
UCEC	p62 Lck ligand →	+0.561	+3.469	<.001	.002	3	1
UCEC	PCNA →	+0.329	+2.999	.002	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

GAPDH by ACOT2 expression — UCEC

Explore this box plot interactively →