ACOT2

Across TCGA cell cohorts, ACOT2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,163 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ACOT2-associated GO terms across cancer lineages are DNA ADP-ribosylation, mRNA 3'-end processing by stem-loop binding and cleavage, and Positive regulation of substrate adhesion-dependent cell spreading. Each is linked with ACOT2 in more than 8 cancer types. Because this analysis shows association rather than direction, both ACOT2-to-partner and partner-to-ACOT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA ADP-ribosylation grouped by ACOT2-low versus ACOT2-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ACOT2→partner) and Y-score (partner→ACOT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	DNA ADP-ribosylation →	+0.131	+0.881	<.001	.008	3	9
SOFT_TISSUE	mRNA 3'-end processing by stem-loop binding and cleavage →	+0.105	+0.859	.002	.004	3	7
BONE	Positive regulation of substrate adhesion-dependent cell spreading →	+0.096	+1.655	.001	.002	3	7
BLOOD_Leukemia	Nucleoside triphosphate biosynthetic process →	+0.046	+1.144	.002	.006	3	7
BONE	Lysosome organization →	+0.053	+2.210	<.001	<.001	3	7
BONE	Lytic vacuole organization →	+0.053	+2.210	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,163 associations by consensus.

DNA ADP-ribosylation by ACOT2 expression — KIDNEY

Explore this box plot interactively →