ACOT2

Across TCGA cell cohorts, ACOT2 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACOT2-associated genes across cancer lineages are ECE2, ELOA3DP, and USP17L7. Each is linked with ACOT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACOT2-to-partner and partner-to-ACOT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ECE2 grouped by ACOT2-low versus ACOT2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACOT2→partner) and Y-score (partner→ACOT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ECE2 →	+0.353	+4.054	<.001	.004	3	1
LARGE_INTESTINE	ELOA3DP →	+0.044	+4.688	<.001	<.001	3	1
LARGE_INTESTINE	USP17L7 →	+0.106	+3.691	<.001	.009	2	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

ECE2 by ACOT2 expression — LARGE_INTESTINE

Explore this box plot interactively →