ACOT13

Across TCGA patient cohorts, ACOT13 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACOT13-associated genes across cancer lineages are Ku80, Notch1, and Tuberin. Each is linked with ACOT13 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACOT13-to-partner and partner-to-ACOT13 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by ACOT13-low versus ACOT13-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACOT13→partner) and Y-score (partner→ACOT13) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.350	+2.183	.004	.035	3	1
UCEC	Notch1 →	+0.253	+3.009	<.001	.019	3	1
UCEC	Tuberin →	+0.291	+2.179	.039	.034	3	1
UCEC	Bak →	+0.443	+3.321	<.001	.010	3	1
UCEC	Caspase-8 →	-0.301	-3.321	.022	.010	3	1
UCEC	c-Met_pY1235 →	+0.099	+3.009	.011	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Ku80 by ACOT13 expression — UCEC

Explore this box plot interactively →