ACOT12

Across TCGA cell cohorts, ACOT12 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BREAST shows the largest number of these associations.

The most reproducible ACOT12-associated genes across cancer lineages are CYP11B1, OR10K2, and PABPC1L2A. Each is linked with ACOT12 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACOT12-to-partner and partner-to-ACOT12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CYP11B1 grouped by ACOT12-low versus ACOT12-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACOT12→partner) and Y-score (partner→ACOT12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CYP11B1 →	+0.023	+4.906	<.001	.006	3	1
BREAST	OR10K2 →	+0.063	+5.781	<.001	.001	3	1
BREAST	PABPC1L2A →	+0.083	+5.169	<.001	.005	3	1
BREAST	OR10T2 →	+0.183	+5.781	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CYP11B1 by ACOT12 expression — OESOPHAGUS

Explore this box plot interactively →