ACOT11

Across TCGA pan-cancer cohorts, ACOT11 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated ACOT11 data layer compared with 26 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher ACOT11 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ACOT11 expression acts as an unfavorable survival marker.

LUSC and SKCM are the cancer types where ACOT11 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	All	0.165	0.648	.004	21	view →
SKCM	DFS	Median	IV	0.036	0.433	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

ACOT11–LUSC (DFS)

Open the LUSC breakdown →