Across TCGA pan-cancer cohorts, ACOT1 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated ACOT1 data layer compared with 28 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ACOT1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ACOT1 expression acts as an unfavorable survival marker.

CCRCC and LUAD are the cancer types where ACOT1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	III,IV	0.363	1.000	.003	22	view →
LUAD	DFS	Tertile	III,IV	0.263	0.768	.012	9	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: ACOT1 tumor-vs-normal RNA expression · all ACOT1 data types