ACO2

Across TCGA pan-cancer cohorts, ACO2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ACO2 data layer compared with 23 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ACO2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ACO2 expression acts as an unfavorable survival marker, although some lineages such as PDAC and OV show a favorable association.

PDAC, OV, and LSCC are the cancer types where ACO2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.373	0.198	.003	29	view →
OV	DFS	Median	All	0.900	0.461	.004	24	view →
LSCC	DFS	Quartile	II,III,IV	0.653	0.886	.030	4	view →
CCRCC	DFS	Quartile	II,III,IV	0.401	0.851	.017	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ACO2–PDAC (DFS)

Open the PDAC breakdown →