ACO2

Across TCGA patient cohorts, ACO2 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACO2-associated genes across cancer lineages are eIF4E, ERK2, and JNK2. Each is linked with ACO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACO2-to-partner and partner-to-ACO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by ACO2-low versus ACO2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACO2→partner) and Y-score (partner→ACO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.157	+2.820	.047	.035	3	2
UCEC	ERK2 →	+0.153	+1.765	.034	.014	3	1
UCEC	JNK2 →	+0.242	+2.009	.001	.017	3	1
UCEC	MEK1 →	+0.382	+2.222	.005	.010	3	1
UCEC	p62 Lck ligand →	+0.292	+3.179	.016	.010	3	1
UCEC	PDCD4 →	-0.433	-1.797	.014	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

eIF4E by ACO2 expression — UCEC

Explore this box plot interactively →