ACO2

Across TCGA cell cohorts, ACO2 mutation is significantly associated with the RNA expression of many other genes, with 31 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ACO2-associated genes across cancer lineages are IL4, HRG, and C20orf85. Each is linked with ACO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACO2-to-partner and partner-to-ACO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL4 grouped by ACO2-low versus ACO2-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACO2→partner) and Y-score (partner→ACO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IL4 →	+2.075	+4.007	<.001	.002	3	1
BLOOD_Leukemia	HRG →	+0.367	+4.177	<.001	.001	3	1
BLOOD_Leukemia	C20orf85 →	+0.027	+3.969	<.001	.009	3	1
BLOOD_Leukemia	DPP6 →	+0.437	+3.623	<.001	.007	3	1
BLOOD_Leukemia	ASZ1 →	+0.109	+4.889	<.001	<.001	3	1
BLOOD_Leukemia	FCRL3 →	+0.999	+3.775	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

IL4 by ACO2 expression — BLOOD_Leukemia

Explore this box plot interactively →