ACO2

Across TCGA cell cohorts, ACO2 mutation is significantly associated with the mutation status of many other genes, with 2,519 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ACO2-associated genes across cancer lineages are ARAP1, PTPN23, and GCN1. Each is linked with ACO2 in more than 3 cancer types. Because this analysis shows association rather than direction, both ACO2-to-partner and partner-to-ACO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ARAP1 grouped by ACO2-low versus ACO2-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACO2→partner) and Y-score (partner→ACO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ARAP1 →	+5.066	+4.502	.007	.007	1	4
BREAST	PTPN23 →	+4.297	+4.857	.009	.009	1	3
BREAST	GCN1 →	+4.297	+4.857	.009	.009	1	3
BREAST	HIVEP2 →	+4.297	+4.857	.009	.009	1	3
UPPER_AERODIGESTIVE_TRACT	TOP3B →	+4.392	+4.954	.008	.008	1	3
BLOOD_Leukemia	CACNA1I →	+2.880	+3.495	.002	.002	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,519 associations by consensus.

ARAP1 by ACO2 expression — LUNG_SCLC

Explore this box plot interactively →