ACO1

Across TCGA pan-cancer cohorts, ACO1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ACO1 data layer compared with 21 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ACO1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ACO1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

LSCC, PDAC, and CCRCC are the cancer types where ACO1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	All	0.902	0.973	.003	20	view →
PDAC	DFS	Median	All	0.568	0.344	.006	9	view →
CCRCC	OS	Median	All	1.000	0.909	.019	5	view →
UCEC	DFS	Median	III,IV	0.445	0.904	.037	4	view →
HNSC	OS	Median	IV	0.931	1.000	.048	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ACO1–LSCC (DFS)

Open the LSCC breakdown →