ACO1

Across TCGA patient cohorts, ACO1 RNA expression is significantly associated with the mutation status of many other genes, with 9,083 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACO1-associated genes across cancer lineages are RYR2, CYFIP1, and PLXND1. Each is linked with ACO1 in more than 3 cancer types. Because this analysis shows association rather than direction, both ACO1-to-partner and partner-to-ACO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RYR2 grouped by ACO1-low versus ACO1-high in UCEC.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACO1→partner) and Y-score (partner→ACO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RYR2 →	+0.890	+0.323	<.001	<.001	3	4
UCEC	CYFIP1 →	+2.044	+0.580	<.001	<.001	3	4
UCEC	PLXND1 →	+1.502	+0.330	.001	.003	3	4
CESC	DNAH6 →	+3.584	+0.413	.002	.005	3	3
LUAD	CNGB3 →	+2.709	+0.531	.003	.002	3	3
UCEC	MUC16 →	+1.084	+0.260	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,083 associations by consensus.

RYR2 by ACO1 expression — UCEC

Explore this box plot interactively →