ACO1

Across TCGA cell cohorts, ACO1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,807 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ACO1-associated GO terms across cancer lineages are Citrate metabolic process, Negative regulation of Rho protein signal transduction, and Response to iron(II) ion. Each is linked with ACO1 in more than 12 cancer types. Because this analysis shows association rather than direction, both ACO1-to-partner and partner-to-ACO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Citrate metabolic process grouped by ACO1-low versus ACO1-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ACO1→partner) and Y-score (partner→ACO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Citrate metabolic process →	+0.164	+1.432	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Negative regulation of Rho protein signal transduction →	+0.152	+1.381	<.001	.001	3	13
LUNG_SCLC	Response to iron(II) ion →	+0.238	+1.141	<.001	<.001	3	13
LUNG_NSCLC_LUSC	Negative regulation of cilium assembly →	+0.065	+1.347	.002	.001	3	12
LUNG_NSCLC_LUAD	Positive regulation of establishment of T cell polarity →	+0.177	+0.845	<.001	<.001	3	12
BONE	Positive regulation of stress fiber assembly →	+0.116	+0.753	.003	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,807 associations by consensus.

Citrate metabolic process by ACO1 expression — KIDNEY

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