ACO1

Across TCGA cell cohorts, ACO1 mutation is significantly associated with the RNA expression of many other genes, with 33 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACO1-associated genes across cancer lineages are OR1C1, BOD1L2, and FSHB. Each is linked with ACO1 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACO1-to-partner and partner-to-ACO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR1C1 grouped by ACO1-low versus ACO1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACO1→partner) and Y-score (partner→ACO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	OR1C1 →	+0.016	+4.906	<.001	.006	3	1
OESOPHAGUS	BOD1L2 →	+0.006	+4.906	<.001	.006	3	1
BLOOD_Lymphoma	FSHB →	+0.012	+5.247	<.001	.001	3	1
BLOOD_Lymphoma	PCARE →	+0.038	+4.523	<.001	.004	3	1
LARGE_INTESTINE	PRSS54 →	+0.029	+3.023	<.001	.002	3	1
LARGE_INTESTINE	CUEDC2 →	+0.810	+3.064	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

OR1C1 by ACO1 expression — OESOPHAGUS

Explore this box plot interactively →