ACO1

Across TCGA cell cohorts, ACO1 mutation is significantly associated with the mutation status of many other genes, with 5,067 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACO1-associated genes across cancer lineages are IL16, OR2V2, and CMYA5. Each is linked with ACO1 in more than 4 cancer types. Because this analysis shows association rather than direction, both ACO1-to-partner and partner-to-ACO1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL16 grouped by ACO1-low versus ACO1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACO1→partner) and Y-score (partner→ACO1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IL16 →	+3.309	+4.794	.002	.002	1	5
BLOOD_Lymphoma	OR2V2 →	+5.247	+4.429	.005	.005	1	4
BREAST	CMYA5 →	+2.857	+4.142	.008	.008	1	4
LUNG_NSCLC_LUAD	USP20 →	+5.339	+4.772	.004	.004	1	4
BLOOD_Leukemia	TDRD1 →	+3.672	+5.083	.001	.001	1	3
SKIN	THSD7A →	+2.977	+4.392	.005	.005	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,067 associations by consensus.

IL16 by ACO1 expression — BLOOD_Leukemia

Explore this box plot interactively →