ACLY

Across TCGA patient cohorts, ACLY RNA expression is significantly associated with the protein abundance of many other proteins, with 18,891 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ACLY-associated proteins across cancer lineages are ACLY_S481, TBC1D2B, and TBXAS1. Each is linked with ACLY in more than 5 cancer types. Because this analysis shows association rather than direction, both ACLY-to-partner and partner-to-ACLY results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ACLY versus ACLY_S481 in LSCC, with a Pearson correlation of 0.58.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ACLY→partner) and Y-score (partner→ACLY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	ACLY_S481 →	+0.427	+0.623	<.001	<.001	3	6
GBM	TBC1D2B →	-0.262	-0.385	<.001	<.001	3	6
UCEC	TBXAS1 →	-0.444	-0.672	.003	.003	3	6
LSCC	EVI2B_S268 →	-0.917	-0.447	<.001	<.001	3	6
LSCC	ARHGDIB →	-0.615	-0.612	<.001	<.001	3	5
GBM	PTPRC →	-0.676	-0.613	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,891 associations by consensus.

ACLY vs ACLY_S481 — LSCC

Explore this scatter interactively →