ACLY

Across TCGA patient cohorts, ACLY protein abundance is significantly associated with the RNA expression of many other genes, with 14,087 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible ACLY-associated genes across cancer lineages are KLHL25, CCDC43, and DUSP26. Each is linked with ACLY in more than 5 cancer types. Because this analysis shows association rather than direction, both ACLY-to-partner and partner-to-ACLY results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ACLY versus KLHL25 in GBM, with a Pearson correlation of -0.55.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACLY→partner) and Y-score (partner→ACLY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	KLHL25 →	-0.826	-0.318	<.001	<.001	3	6
LSCC	CCDC43 →	+0.576	+0.246	<.001	<.001	3	6
GBM	DUSP26 →	-1.168	-0.307	.001	<.001	3	5
COAD	FLI1 →	-0.576	-0.193	<.001	.002	3	5
BRCA	SCD →	+1.380	+0.339	<.001	<.001	3	5
OV	LRRC59 →	+0.715	+0.323	<.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,087 associations by consensus.

ACLY vs KLHL25 — GBM

Explore this scatter interactively →