ACLY

Across TCGA patient cohorts, ACLY mutation is significantly associated with the RNA expression of many other genes, with 2,015 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACLY-associated genes across cancer lineages are MRPL51P2, RBPJP6, and EIF5A. Each is linked with ACLY in more than 3 cancer types. Because this analysis shows association rather than direction, both ACLY-to-partner and partner-to-ACLY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL51P2 grouped by ACLY-low versus ACLY-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACLY→partner) and Y-score (partner→ACLY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MRPL51P2 →	+0.055	+5.153	<.001	.001	3	4
SKCM	RBPJP6 →	+0.013	+3.748	.004	.002	3	3
UCEC	EIF5A →	+0.310	+2.058	.003	<.001	3	3
STAD	DLGAP5P1 →	+0.176	+4.567	<.001	.008	3	3
CESC	RNU6-859P →	+0.301	+3.411	<.001	.009	3	2
CESC	ATP5PBP3 →	+0.165	+3.847	.003	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,015 associations by consensus.

MRPL51P2 by ACLY expression — COAD

Explore this box plot interactively →