ACLY

Across TCGA patient cohorts, ACLY mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACLY-associated genes across cancer lineages are eEF2, ERK2, and MEK1. Each is linked with ACLY in more than 2 cancer types. Because this analysis shows association rather than direction, both ACLY-to-partner and partner-to-ACLY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eEF2 grouped by ACLY-low versus ACLY-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACLY→partner) and Y-score (partner→ACLY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eEF2 →	+0.318	+2.222	.011	.009	3	3
UCEC	ERK2 →	+0.136	+1.584	.045	.034	3	2
UCEC	MEK1 →	+0.403	+2.700	.001	.005	3	2
UCEC	MSH2 →	-0.322	-3.781	<.001	<.001	3	2
UCEC	Rab25 →	-0.426	-1.906	<.001	.015	3	2
UCEC	BRD4 →	+0.206	+3.321	.029	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

eEF2 by ACLY expression — UCEC

Explore this box plot interactively →