ACLY

Across TCGA cell cohorts, ACLY RNA expression is significantly associated with the go_rna of many other GO terms, with 3,858 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ACLY-associated GO terms across cancer lineages are rRNA 5'-end processing, Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA), and Positive regulation of mitotic cytokinesis. Each is linked with ACLY in more than 13 cancer types. Because this analysis shows association rather than direction, both ACLY-to-partner and partner-to-ACLY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, rRNA 5'-end processing grouped by ACLY-low versus ACLY-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ACLY→partner) and Y-score (partner→ACLY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	rRNA 5'-end processing →	+0.108	+0.858	<.001	<.001	3	14
PANCREAS	Endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.108	+0.858	<.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Positive regulation of mitotic cytokinesis →	+0.175	+0.952	.001	.004	2	14
UPPER_AERODIGESTIVE_TRACT	Nuclear transport →	+0.080	+1.054	<.001	<.001	3	13
PANCREAS	DNA-templated transcription initiation →	+0.065	+0.944	<.001	<.001	3	13
UPPER_AERODIGESTIVE_TRACT	Regulation of transcription by RNA polymerase I →	+0.080	+0.854	.003	.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,858 associations by consensus.

rRNA 5'-end processing by ACLY expression — PANCREAS

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