ACLY

Across TCGA cell cohorts, ACLY mutation is significantly associated with the RNA expression of many other genes, with 297 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACLY-associated genes across cancer lineages are SCGB1C1, SERPINA12, and FTMT. Each is linked with ACLY in more than 1 cancer types. Because this analysis shows association rather than direction, both ACLY-to-partner and partner-to-ACLY results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCGB1C1 grouped by ACLY-low versus ACLY-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACLY→partner) and Y-score (partner→ACLY) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	SCGB1C1 →	+0.253	+4.981	<.001	.008	3	2
SOFT_TISSUE	SERPINA12 →	+0.008	+4.392	<.001	.004	3	1
SOFT_TISSUE	FTMT →	+0.052	+4.392	<.001	.004	3	1
SOFT_TISSUE	PIRT →	+0.035	+3.865	.001	.006	3	1
SKIN	CD8A →	+0.348	+3.339	<.001	.007	3	1
LARGE_INTESTINE	MTHFD1 →	+0.658	+3.364	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 297 associations by consensus.

SCGB1C1 by ACLY expression — CNS

Explore this box plot interactively →