Across TCGA pan-cancer cohorts, ACKR4P1 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ACKR4P1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ACKR4P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ACKR4P1 is over-expressed in tumor, although a few such as STAD and UCEC show the opposite, repressed pattern.

HNSC, STAD, and UCEC are the cancer types where ACKR4P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ACKR4P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.048	<.001	6	view →
STAD	All	IV	−0.153	.012	4	view →
UCEC	All	All	−0.137	.021	2	view →
KIRC	Male	IV	+0.021	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: ACKR4P1 RNA expression & survival · all ACKR4P1 data types