ACKR4

Across TCGA cell cohorts, ACKR4 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,884 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ACKR4-associated GO terms across cancer lineages are Flagellated sperm motility, Sperm motility, and Oxidative demethylation. Each is linked with ACKR4 in more than 7 cancer types. Because this analysis shows association rather than direction, both ACKR4-to-partner and partner-to-ACKR4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Flagellated sperm motility grouped by ACKR4-low versus ACKR4-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ACKR4→partner) and Y-score (partner→ACKR4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Flagellated sperm motility →	-0.071	-0.261	.007	.005	3	8
UPPER_AERODIGESTIVE_TRACT	Sperm motility →	-0.071	-0.261	.007	.005	3	8
BONE	Oxidative demethylation →	-0.198	-0.202	.005	<.001	2	8
LUNG_NSCLC_LUSC	Double-strand break repair →	+0.062	+0.367	.005	.002	3	7
LUNG_NSCLC_LUSC	Microtubule organizing center organization →	+0.074	+0.304	.004	.001	3	6
LARGE_INTESTINE	Centrosome duplication →	+0.096	+0.382	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,884 associations by consensus.

Flagellated sperm motility by ACKR4 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →