ACKR3

Across TCGA pan-cancer cohorts, ACKR3 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ACKR3 data layer compared with 24 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ACKR3 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated ACKR3 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

HNSC, LUAD, and GBM are the cancer types where ACKR3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	All	0.725	1.000	.003	33	view →
LUAD	DFS	Tertile	All	0.721	0.063	.038	3	view →
GBM	DFS	Median	All	0.187	0.509	.033	2	view →
LSCC	DFS	Quartile	All	0.700	0.875	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ACKR3–HNSC (OS)

Open the HNSC breakdown →