ACKR3

Across TCGA cell cohorts, ACKR3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,819 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible ACKR3-associated GO terms across cancer lineages are Endodermal cell differentiation, Tissue remodeling, and Oculomotor nerve development. Each is linked with ACKR3 in more than 8 cancer types. Because this analysis shows association rather than direction, both ACKR3-to-partner and partner-to-ACKR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endodermal cell differentiation grouped by ACKR3-low versus ACKR3-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ACKR3→partner) and Y-score (partner→ACKR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Endodermal cell differentiation →	+0.199	+4.065	.002	.004	3	8
SKIN	Tissue remodeling →	+0.075	+2.089	.007	.002	3	8
KIDNEY	Oculomotor nerve development →	+0.972	+3.836	.005	.003	3	8
URINARY_TRACT	Negative regulation of transforming growth factor beta production →	+0.332	+4.520	<.001	<.001	3	8
STOMACH	Intrinsic apoptotic signaling pathway →	+0.031	+2.164	.005	<.001	3	8
KIDNEY	Apoptotic cell clearance →	+0.244	+4.668	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,819 associations by consensus.

Endodermal cell differentiation by ACKR3 expression — LIVER

Explore this box plot interactively →