ACKR2

Across TCGA patient cohorts, ACKR2 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ACKR2-associated genes across cancer lineages are Stathmin, EGFR_pY1068, and eIF4E. Each is linked with ACKR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACKR2-to-partner and partner-to-ACKR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Stathmin grouped by ACKR2-low versus ACKR2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACKR2→partner) and Y-score (partner→ACKR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Stathmin →	+0.179	+2.195	.031	.032	3	1
UCEC	EGFR_pY1068 →	-0.227	-2.321	.013	.005	3	1
UCEC	eIF4E →	+0.203	+2.713	.008	.003	3	1
UCEC	ACC1 →	+0.306	+3.183	.022	.009	3	1
UCEC	HER2_pY1248 →	-0.197	-1.847	.044	.008	3	1
UCEC	JNK_pT183_Y185 →	-0.136	-2.000	.027	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Stathmin by ACKR2 expression — SKCM

Explore this box plot interactively →