ACKR2

Across TCGA cell cohorts, ACKR2 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ACKR2-associated genes across cancer lineages are C1QTNF7, TRARG1, and ADGRA1. Each is linked with ACKR2 in more than 1 cancer types. Because this analysis shows association rather than direction, both ACKR2-to-partner and partner-to-ACKR2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1QTNF7 grouped by ACKR2-low versus ACKR2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ACKR2→partner) and Y-score (partner→ACKR2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C1QTNF7 →	+0.130	+4.108	<.001	.008	3	1
LARGE_INTESTINE	TRARG1 →	+0.027	+3.930	<.001	.003	3	1
BLOOD_Leukemia	ADGRA1 →	+0.006	+5.201	<.001	.006	3	1
BLOOD_Leukemia	TLE7 →	+0.046	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

C1QTNF7 by ACKR2 expression — LARGE_INTESTINE

Explore this box plot interactively →