Across TCGA pan-cancer cohorts, ACKR1 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated ACKR1 data layer compared with 27 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ACKR1 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated ACKR1 expression acts as an unfavorable survival marker, although some lineages such as STAD and UCEC show a favorable association.

HNSC, STAD, and SARC are the cancer types where ACKR1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.087	0.710	<.001	18	view →
STAD	OS	Median	IV	1.000	0.313	.023	9	view →
SARC	DFS	Median	All	0.065	0.632	<.001	6	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
UCEC	DFS	Median	All	0.951	0.627	.034	2	view →
SKCM	DFS	Median	All	0.419	0.760	.043	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

Exploration

Same gene, other analysis: ACKR1 tumor-vs-normal RNA expression · all ACKR1 data types